serum levels of natriuretic peptides in children before and after treatment for an atrial septal defect, a patent ductus arteriosus, and a coarctation of the aorta—a prospective study儿童血清钠尿肽水平治疗前后的心房中隔缺损,动脉导管未闭、主动脉缩窄的前瞻性研究.pdfVIP

Hindawi Publishing Corporation International Journal of Pediatrics Volume 2010, Article ID 674575, 9 pages doi:10.1155/2010/674575 Research Article Serum Levels of Natriuretic Peptides in Children before and after Treatment for an Atrial Septal Defect, a Patent Ductus Arteriosus, and a Coarctation of the Aorta—A Prospective Study Anneli Eerola,1, 2 Eero Jokinen,2 Talvikki Boldt,2 Ilkka P. Mattila,3 and Jaana I. Pihkala2 1 Department of Pediatrics, University Hospital of Tampere, 33521 Tampere, Finland 2 Department of Pediatric Cardiology, Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland 3 Department of Pediatric Cardiac Surgery, Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland Correspondence should be addressed to Anneli Eerola, anneli.eerola@fimnet.fi Received 27 September 2009; Revised 13 December 2009; Accepted 8 February 2010 Academic Editor: Amiram Nir Copyright © 2010 Anneli Eerola et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background and Objectives. We evaluated and compared the influence of treatment for atrial septal defect (ASD), patent ductus arteriosus (PDA), and coarctation of the aorta (CoA) on serum levels of N-terminal proatriopeptide and N-terminal probrain natriuretic peptide. Correlations between peptide levels and echocardiographic measurements were calculated. Patients and Methods. Peptide levels were measured and echocardiography performed before and 6–12 months after treatment in 21 children with ASD, 25 with PDA, 15 with CoA, and 76 control children. Results. ANPN levels were higher than in controls at baseline in all