sesamin a naturally occurring lignan inhibits cyp3a4 by antagonizing the pregnane x receptor activation芝麻素是一种天然的木酚素抑制cyp3a4得罪了孕烷x受体激活.pdfVIP

Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2012, Article ID 242810, 15 pages doi:10.1155/2012/242810 Research Article Sesamin: A Naturally Occurring Lignan Inhibits CYP3A4 by Antagonizing the Pregnane X Receptor Activation Yun-Ping Lim,1, 2 Chia-Yun Ma,1 Cheng-Ling Liu,3 Yu-Hsien Lin,1 Miao-Lin Hu,3 Jih-Jung Chen,4 Dong-Zong Hung,1, 2 Wen-Tsong Hsieh,5 and Jin-Ding Huang6, 7 1 Department of Pharmacy, College of Pharmacy, China Medical University, Taichung 40402, Taiwan 2 Department of Emergency, Toxicology Center, China Medical University Hospital, Taichung 40447, Taiwan 3 Department of Food Science and Biotechnology, National Chung Hsing University, Taichung 40227, Taiwan 4 Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 90741, Taiwan 5 School of Medicine and Graduate Institute of Basic Medical Science, China Medical University, Taichung 40402, Taiwan 6 Institute of Biopharmaceutical Sciences, Medical College, National Cheng Kung University, Tainan 70101, Taiwan 7 Department of Pharmacology, Medical College, National Cheng Kung University, Tainan 70101, Taiwan Correspondence should be addressed to Yun-Ping Lim, limyp@.tw Received 14 December 2011; Revised 30 January 2012; Accepted 6 February 2012 Academic Editor: Pradeep Visen Copyright © 2012 Yun-Ping Lim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Inconsistent expression and regulation of drug-metabolizing enzymes (DMEs) are common causes of adverse drug effects in some drugs with a narrow therapeutic index (TI). An important cytochrome, cytochrome P450 3A4 (CYP3A4),