soluble host defense lectins in innate immunity to influenza virus可溶性宿主防御在先天免疫凝集素对流感病毒.pdfVIP

Hindawi Publishing Corporation Journal of Biomedicine and Biotechnology Volume 2012, Article ID 732191, 14 pages doi:10.1155/2012/732191 Review Article Soluble Host Defense Lectins in Innate Immunity to Influenza Virus Wy Ching Ng,1 Michelle D. Tate,1, 2 Andrew G. Brooks,1 and Patrick C. Reading1, 3 1 Department of Microbiology and Immunology, The University of Melbourne, Parkville, VIC 3010, Australia 2 Centre for Innate Immunity and Infectious Disease, Monash Institute of Medical Research, Monash University, Clayton, VIC 3168, Australia 3 WHO Collaborating Centre for Reference and Research on Influenza, Victorian Infectious Diseases Reference Laboratory, North Melbourne, VIC 3051, Australia Correspondence should be addressed to Patrick C. Reading, preading@.au Received 20 December 2011; Accepted 21 February 2012 Academic Editor: Nobutaka Wakamiya Copyright © 2012 Wy Ching Ng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Host defenses against viral infections depend on a complex interplay of innate (nonspecific) and adaptive (specific) components. In the early stages of infection, innate mechanisms represent the main line of host defense, acting to limit the spread of virus in host tissues prior to the induction of the adaptive immune response. Serum and lung fluids contain a range of lectins capable of recognizing and destroying influenza A viruses (IAV). Herein, we review the mechanisms by which soluble endogenous lectins mediate anti-IAV activity, including their role in modulating IAV-induced inflammation and disease and their potential as prophylactic and/or therapeutic