schistosome its benefit and harm in patients suffering from concomitant diseases血吸虫的益处和害处患者伴随的疾病.pdfVIP

Hindawi Publishing Corporation Journal of Biomedicine and Biotechnology Volume 2011, Article ID 264173, 10 pages doi:10.1155/2011/264173 Review Article Schistosome: Its Benefit and Harm in Patients Suffering from Concomitant Diseases Yoshio Osada and Tamotsu Kanazawa Department of Immunology and Parasitology, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan Correspondence should be addressed to Yoshio Osada, yosada@med.uoeh-u.ac.jp Received 1 July 2011; Accepted 6 September 2011 Academic Editor: Luis I. Terrazas Copyright © 2011 Y. Osada and T. Kanazawa. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Schistosomiasis is an important tropical disease affecting approximately 200 million people worldwide. Because of its chronicity and robust immunomodulatory activity, the effects of schistosomes on other diseases, such as allergies, autoimmunity, and infectious diseases, have been studied extensively in both epidemiological and experimental settings. In this paper, we summarize the beneficial and harmful effects of schistosomes. The importance of controlling schistosomiasis is also discussed. 1. Introduction omega-1, IPSE, and peroxiredoxin) are involved in the Th2-biasing activity [7– 11]. In addition, schistosome eggs Schistosoma spp., blood flukes, are parasitic helminths found have immunomodulatory potential inducing the alternative mainly in developing countries with a tropical or subtropical activation of macrophages [12