spatial and temporal dynamics in the ionic driving force for gabaa receptors时空动力学gabaa受体离子动力.pdfVIP

Hindawi Publishing Corporation Neural Plasticity Volume 2011, Article ID 728395, 10 pages doi:10.1155/2011/728395 Review Article Spatial and Temporal Dynamics in the Ionic Driving Force for GABAA Receptors R. Wright, J. V. Raimondo, and C. J. Akerman Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK Correspondence should be addressed to C. J. Akerman, colin.akerman@pharm.ox.ac.uk Received 21 January 2011; Accepted 29 March 2011 Academic Editor: Laura Cancedda Copyright © 2011 R. Wright et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. It is becoming increasingly apparent that the strength of GABAergic synaptic transmission is dynamic. One parameter that can establish differences in the actions of GABAergic synapses is the ionic driving force for the chloride-permeable GABAA receptor (GABA R). Here we review some of the sophisticated ways in which this ionic driving force can vary within neuronal circuits. A This driving force for GABAA Rs is subject to tight spatial control, with the distribution of Cl− transporter proteins and channels generating regional variation in the strength of GABA R signalling across a single neuron. GABA R dynamics can result from A A short-term changes in their driving force, which involve the temporary accumulation or depletion of intracellular Cl− . In addition, activity-dependent changes in the expression and function of Cl− regulating proteins can result in long-term shifts in the driving force