the current role of androgen deprivation in patients undergoing dose-escalated external beam radiation therapy for clinically localized prostate cancer当前角色的雄激素剥夺病人接受dose-escalated体外放射治疗临床局限性前列腺癌.pdfVIP

Hindawi Publishing Corporation Prostate Cancer Volume 2012, Article ID 280278, 8 pages doi:10.1155/2012/280278 Review Article The Current Role of Androgen Deprivation in Patients Undergoing Dose-Escalated External Beam Radiation Therapy for Clinically Localized Prostate Cancer Michael J. Smith,1 Naveed H. Akhtar,2 and Scott T. Tagawa2, 3 1 Department of Radiation Oncology, Stitch Radiation Center, Weill Cornell Medical College, 525 East 68th Street, P.O. Box 575, New York, NY 10065, USA 2 Division of Hematology Medical Oncology, Weill Cornell Medical College, 525 East 68th Street, New York, NY 10065, USA 3 Department of Urology, Weill Cornell Medical College, 525 East 68th Street, New York, NY 10065, USA Correspondence should be addressed to Michael J. Smith, mis9146@ Received 16 July 2011; Revised 4 January 2012; Accepted 13 January 2012 Academic Editor: May Abdel-Wahab Copyright © 2012 Michael J. Smith et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Purpose. To review existing literature on the role of androgen deprivation therapy (ADT) with dose escalated radiation therapy. Methods and Materials. A PubMed search was undertaken to identify relevant articles. Results. Multiple recent studies were identified examining the role of ADT in the current era of radiation dose-escalation. Among the reviewed studies, varying radiation doses and techniques, ADT regimens, and patient selection criteria were utilized. Conflicting results were reported, with some studies demonstrating a benefit of delivering a higher radiation dose with ADT. Other studies failed to show s