the effect of antivascular endothelial growth factor on the development of adhesion formation in laparotomized rats experimental studyantivascular内皮生长因子的影响附着力的发展形成laparotomized老鼠实验研究.pdfVIP

Hindawi Publishing Corporation Gastroenterology Research and Practice Volume 2011, Article ID 578691, 8 pages doi:10.1155/2011/578691 Research Article The Effect of Antivascular Endothelial Growth Factor on the Development of Adhesion Formation in Laparotomized Rats: Experimental Study Murat Basbug,1 Nurullah Bulbuller,2 Cemalettin Camci,2 Refik Ayten,2 Erhan Aygen,2 Ibrahim Hanifi Ozercan,3 Zulfu Arikanoglu,1 and Sami Akbulut1 1 Department of General Surgery, Diyarbakir Education and Research Hospital, 21400 Diyarbakir, Turkey 2 Department of General Surgery, Faculty of Medicine, Firat University, 23100 Elazig, Turkey 3 Department of Medical Pathology, Faculty of Medicine, Firat University, 23100 Elazig, Turkey Correspondence should be addressed to Sami Akbulut, akbulutsami@ Received 16 February 2011; Accepted 2 May 2011 Academic Editor: Hirozumi Sawai Copyright © 2011 Murat Basbug et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Aims. This study determined the effects of a single dose of bevacizumab, an antiangiogenic recombinant monoclonal antibody that specifically targets vascular endothelial growth factor (VEGF), on adhesion formation in the rat cecal abrasion model. Methodology. Thirty female Wistar albino rats (200–224 g) were divided into three groups. All rats underwent laparotomy at which time cecal wall abrasion and abdominal wall injuries were induced. Group I (control) underwent only the abrasion procedure; Groups II and III received saline or bevacizumab intraperitoneally, respectively, following the abrasion. The rats were killed on postoperative