the plasminogen receptor, , and macrophage function纤溶酶原受体,物,巨噬细胞的功能.pdfVIP

Hindawi Publishing Corporation Journal of Biomedicine and Biotechnology Volume 2012, Article ID 250464, 14 pages doi:10.1155/2012/250464 Review Article The Plasminogen Receptor, Plg-RKT, and Macrophage Function Lindsey A. Miles,1 Shahrzad Lighvani,1 Nagyung Baik,1 Nicholas M. Andronicos,2 Emily I. Chen,3 Caitlin M. Parmer,4 Sophia Khaldoyanidi,5 Jenna E. Diggs,1 William B. Kiosses,1 Mark P. Kamps,6 John R. Yates III,1 and Robert J. Parmer7, 8 1 Department of Cell Biology, The Scripps Research Institute, 10550 N. Torrey Pines Road, SP30-3020, La Jolla, CA 92037, USA 2 CSIRO Livestock Industries, Armidale, NSW, Australia 3 Department of Pharmacology and Pathology, Stony Brook University, Stony Brook, NY 11794, USA 4 Yale University, New Haven, CT 06520, USA 5 Department of Regenerative Medicine, Torrey Pines Institute for Molecular Studies, La Jolla, CA 92121, USA 6 Department of Pathology, University of California San Diego, San Diego, CA 92093, USA 7 Department of Medicine, University of California San Diego, San Diego, CA 92093, USA 8 Department of Medicine, Veterans Administration San Diego Healthcare System, San Diego, CA 92161, USA Correspondence should be addressed to Lindsey A. Miles, lmiles@ Received 20 March 2012; Accepted 6 June 2012 Academic Editor: Edward F. Plow Copyright © 2012 Lindsey A. Miles et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. When plasminogen binds to cells its activation to plasmin is markedly enhanced compared to the reaction in solution. Thus, cells become armed with the broad spectrum proteolytic activity o