the chemical interplay between nitric oxide and mitochondrial cytochrome c oxidase reactions, effectors and pathophysiology化学相互作用一氧化氮和线粒体细胞色素c氧化酶反应,效果器和病理生理学.pdfVIP

Hindawi Publishing Corporation International Journal of Cell Biology Volume 2012, Article ID 571067, 11 pages doi:10.1155/2012/571067 Review Article The Chemical Interplay between Nitric Oxide and Mitochondrial Cytochrome c Oxidase: Reactions, Effectors and Pathophysiology 1, 2 1 ` 2 2 Paolo Sarti, Elena Forte, Alessandro Giuffre, Daniela Mastronicola, Maria Chiara Magnifico,1 and Marzia Arese1 1 Department of Biochemical Sciences and Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy 2 CNR Institute of Molecular Biology and Pathology, Piazzale Aldo Moro 5, 00185 Rome, Italy Correspondence should be addressed to Paolo Sarti, paolo.sarti@uniroma1.it Received 17 February 2012; Accepted 23 March 2012 ˜ Academic Editor: Juan P. Bolanos Copyright © 2012 Paolo Sarti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Nitric oxide (NO) reacts with Complex I and cytochrome c oxidase (CcOX, Complex IV), inducing detrimental or cytoprotective effects. Two alternative reaction pathways (PWs) have been described whereby NO reacts with CcOX, producing either a relatively labile nitrite-bound derivative (CcOX-NO2 −, PW1) or a more stable nitrosyl-derivative (CcOX-NO, PW2). The two derivatives are both inhibited, displaying different persistency and O competitiveness. In the mitochondrion, during turnover with O , 2