the possible role of tumor necrosis factor-α in diabetic polyneuropathy肿瘤坏死的可能作用factor-α糖尿病多神经病.pdfVIP

Experimental Diab. Res., 4:65–71, 2003 c Copyright Taylor and Francis Inc. ISSN: 1543-8600 print / 1543-8619 online DOI: 10.1080/15438600390228496 REVIEW The Possible Role of Tumor Necrosis Factor-α in Diabetic Polyneuropathy Jo Satoh,1 Soroku Yagihashi,2 and Takayoshi Toyota3 1Division of Molecular Metabolism and Diabetes, Department of Internal Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan 2 The First Department of Pathology, Hirosaki University School of Medicine, Hirosake, Japan 3Tohoku Rosai Hospital, Sendai, Japan sequently revealed that various cells, such as fibroblasts, ep- In this review, the authors provide evidences that im- ithelial cells, adipocytes, and myocytes, also produce TNF-α, ply the role of tumor necrosis factor-α (TNF-α) in the which has a variety of biological activities. It has been indi- pathogenesis of diabetic complications, especially diabetic cated that TNF-α plays a role in the pathogenesis of not only polyneuropathy. Under chronic hyperglycemia, endoge- type 1 diabetes mellitus [1] but also type 2 diabetes mellitus nous TNF-α production is accelerated in microvascular and neural tissues, which may undergo an increased microvas- [2]. Recent studies have further disclosed that this peptide con- cular permeability, hypercoagulability, and nerve damage, tributes to the development of diabetic complications [3, 4]. thus initiating and promoting the development of charac- In this review, we propose a hypothesis on a possible role of teristic lesions of diabetic microangiopathy and polyneu- TNF-α in chronic diabetic complications, especially in diabetic rop