the potential interplay of adipokines with toll-like receptors in the development of hepatocellular carcinoma发病的潜在相互作用与toll样受体在肝癌的发展.pdfVIP

Hindawi Publishing Corporation Gastroenterology Research and Practice Volume 2011, Article ID 215986, 10 pages doi:10.1155/2011/215986 Review Article The Potential Interplay of Adipokines with Toll-Like Receptors in the Development of Hepatocellular Carcinoma Shen-Nien Wang,1, 2, 3 Sen-Te Wang,4, 5 and King Teh Lee1, 6 1 Department of Surgery, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan 2 Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan 3 Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan 4 Department of Family Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan 5 Department of Family Medicine, Taipei Medical University Hospital, Taipei, Taiwan 6 Division of Hepatobiliary Surgery, Department of Surgery, Kaohsiung Medical University Hospital, No. 100, Shih-Chuan 1st Road, San Ming District, Kaohsiung 80756, Taiwan Correspondence should be addressed to King Teh Lee, ktlee@.tw Received 30 May 2011; Revised 2 August 2011; Accepted 2 August 2011 Academic Editor: A. Andoh Copyright © 2011 Shen-Nien Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Toll-like receptors (TLRs) are not only crucial to the initiation of the immune system, but also play a key role in several human inflammatory diseases. Hepatocellular carcinoma (HCC) is among those human cancers, which arise from sites of chronic inflammation. Therefore, a number of studies have explored the potential contribution of TLRs to HCC occ