the regenerating gene i is overexpressed in atrophic gastritis rats with hypergastrinemia我再生基因过表达在萎缩性胃炎有hypergastrinemia的老鼠.pdfVIP

Hindawi Publishing Corporation Gastroenterology Research and Practice Volume 2011, Article ID 403956, 7 pages doi:10.1155/2011/403956 Research Article The Regenerating Gene Iα Is Overexpressed in Atrophic Gastritis Rats with Hypergastrinemia Shujie Chen,1 Jing Zhong,2 Qunyan Zhou,1 Xiaofeng Lu,1 Liangjing Wang,2 and Jianmin Si1 1 Laboratory of Digestive Disease, Sir Run Run Shaw Clinical Medicine Institution of Zhejiang University, Hangzhou 310003, China 2 Department of Gastroenterology, Second Affi liated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China Correspondence should be addressed to Liangjing Wang, wanglj76@ and Jianmin Si, sijm@ Received 8 July 2011; Accepted 25 July 2011 Academic Editor: A. Andoh Copyright © 2011 Shujie Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The role of gastrin on the development of atrophic gastritis (AG) and its relationship with the expression of RegIα in vivo remain unclear. We established experimental AG in rats by combination administration with sodium salicylate, alcohol, and deoxycholate sodium. The mean score of inflammation in gastric antrum in AG rats was significantly elevated (P 0.05), while the number of glands dramatically decreased (P 0.05). In addition, the cell proliferation in gastric glands was increased in experimental AG rats, as determined by immunohistochemistry staining of PCNA and GS II. The level of serum gastrin in AG rats was significantly elevated relative to that of normal rats (P 0.01). Moreover, the expression of RegIα protein and its receptor mRNA was increased in gastric tissues in AG rats (