the relationship between cholesterol absorption and intestinal cholesterol synthesis in the diabetic rat model胆固醇和肠道吸收胆固醇合成之间的关系在糖尿病大鼠模型.pdfVIP

Int. Jnl. Experimental Diab. Res., Vol. 1, pp. 203-210 (C) 2000 OPA (Overseas Publishers Association) N.V. Reprints available directly from the publisher Published by license under Photocopying permitted by license only the Harwood Academic Publishers imprint, part of The Gordon and Breach Publishing Group. Printed in Malaysia. The Relationship Between Cholesterol Absorption and Intestinal Cholesterol Synthesis in the Diabetic Rat Model AINE GLEESONa, DAPHNE OWENSa, PATRICK COLLINSb, ALAN JOHNSONb and GERALD H. TOMKINa’c’* aDepartment of Clinical Medicine, Trinity College Dublin; bDepartment of Biochemistry, Royal College of Surgeons in Ireland; CThe Adelaide and Meath Hospital, Dublin. (Received in final form 14 December 1999) The chylomicron remnant particle is thought to be p0.03). There was a positive correlation between particularly atherogenic and we have previously apo B48 and cholesterol absorption (r 0.70, p 0.01) shown alterations in post-prandial lipoproteins in the diabetic rats and control rats (r=0.71, p 0.01) which could contribute to their atherogenicity. but no correlation between apo B48 and cholesterol Cholesterol metabolism is disturbed in diabetes, yet synthesis in either group. This study demonstrates the effect of diabetes on intestinal cholesterol synth- that cholesterol synthesis was increased in diabetes esis and absorption has rarely been investigated. The whereas cholesterol absorption was unaffected sug- aim of this study was to examine