the relationship between reactive oxygen species and cardiac fibrosis in the dahl salt-sensitive rat under acei administration活性氧和心脏纤维化之间的关系在达尔食盐过敏鼠acei管理.pdfVIP

Hindawi Publishing Corporation Veterinary Medicine International Volume 2012, Article ID 105316, 6 pages doi:10.1155/2012/105316 Research Article The Relationship between Reactive Oxygen Species and Cardiac Fibrosis in the Dahl Salt-Sensitive Rat under ACEI Administration Ryou Tanaka and Miki Shimizu Department of Veterinary Surgery, Faculty of Veterinary Medicine, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo 183-8509, Japan Correspondence should be addressed to Ryou Tanaka, ryo@vet.ne.jp Received 11 October 2011; Revised 23 December 2011; Accepted 24 December 2011 Academic Editor: Jyoji Yamate Copyright © 2012 R. Tanaka and M. Shimizu. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Enalapril maleate, the oldest and most widely distributed ACEI, and alacepril, the newest and antioxidant ACEI, were compared in the point of cardioprotective effect for Dahl salt-sensitive rat. In order to evaluate the correlation between the three factors, cardiac fibrosis and blood pressure/oxidative-stress marker (tissue TBARS), index of correlation was calculated. The results showed a significant difference in cardiac fibrosis between high-dose alacepril (30 mg/kg/day, group H) and enalapril maleate (10 mg/kg/day, group E). There was significant correlation between cardiac fibrosis and oxidative-stress marker, although there was no correlation between cardiac fibrosis and blood pressure. Fibrosis was more influenced by oxidative stress not by blood pressure, we should not select ACEI only by blood pressure-lowering effect and should more consider cardioprotective effects of ACEI. 1. Introductio