the effect of acid-reducing pharmacotherapy on the severity of nausea and vomiting of pregnancy未服用药物治疗的影响严重的恶心和呕吐的怀孕.pdfVIP

Hindawi Publishing Corporation Obstetrics and Gynecology International Volume 2009, Article ID 585269, 4 pages doi:10.1155/2009/585269 Research Article The Effect of Acid-Reducing Pharmacotherapy on the Severity of Nausea and Vomiting of Pregnancy Simerpal Kaur Gill,1, 2 Caroline Maltepe,1 Katayoon Mastali,1 and Gideon Koren1, 2 1 The Motherisk Program, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada M5G 1X8 2 Department of Pharmacology, University of Toronto, Toronto, ON, Canada M5S 1A8 Correspondence should be addressed to Gideon Koren, gkoren@sickkids.ca Received 1 October 2008; Revised 25 March 2009; Accepted 12 May 2009 Recommended by William A. Grobman Background. Heartburn and acid reflux (HB/RF) are associated with increased severity of nausea and vomiting. The ability of acid- reducing drugs to reduce symptoms of nausea and vomiting of pregnancy has not been previously tested. Objective. To determine whether acid-reducing pharmacotherapy decreases the severity of NVP symptoms. Methods. We studied a cohort of women experiencing NVP, who were also experiencing HB/RF. Women were counseled to commence acid-reducing pharmacotherapy. The effectiveness of the acid-reducing medication in decreasing symptoms of both HB/RF and NVP was measured. Results. Acid- reducing drugs resulted in significant decreases in PUQE (9.6 ± 3.0 to 6.5 ± 2.5, P .0001) and well-being scores from the initial (4.0 ± 2.0) to the follow-up interview (6.8 ± 1.6, P .0001). After intervention with acid-reducing pharmacotherapy, a reduction in acid symptoms correlated significantly with reduction in NVP (R2 = 0.72, P .001). Conclusion. This is the first study to demonstrate that management of HB/RF can reduce the severity of NVP. Copyright © 2009 Si