型糖尿病患者血尿酸水平与糖尿病肾病关系的研究进展.PDFVIP

海南医学2013 年2 月第24 卷第4 期 doi:10.3969/j.issn.1003-6350.2013.04.0250 ·综 述· 2 型糖尿病患者血尿酸水平与糖尿病肾病关系的研究进展 汪开琳，梁干雄 （广东医学院内分泌科，广东 湛江 524000） 【摘要】 血尿酸(SUA)是嘌呤代谢的终末产物，2/3 由肾脏排泄。尿酸生成增多或排泄减少均可引起高尿酸 血症（HUA ）。既往认为高尿酸血症对人体的影响主要是尿酸盐沉积在关节腔及肾脏，引起相应病变。近期许多 研究表明高尿酸血症与糖尿病的发生、发展密切相关，可作为2 型糖尿病（T2DM ）患者肾脏病变进展的一个独立 危险因素。本文就对血尿酸水平与糖尿病肾病(DN)之间的相互关系做一综述。 【关键词】 2 型糖尿病；血清尿酸；糖代谢紊乱；糖尿病肾病 【中图分类号】 R587.2 【文献标识码】A 【文章编号】 1003—6350（2013 ）04—0576—03 Research progress of the relationship between serum uric acid level and diabetic nephropathy in patients with type 2 diabetes mellitus. WANGKai-lin,LIANGGan-xiong.DepartmentofEndocrinology，GuangdongMedicalCol- lege,Zhanjiang524000,Guangdong,CHINA 【Abstract 】 Serum uric acid (SUA) is an end product of purine metabolism and two-third is excreted by the kidneys. Both increased generation and decreased excretion of uric acid can cause hyperuricemia (HUA). As we all know, the main effect of hyperuricemia is that uric acid salt deposits in articular cavity and kidney, causing the corre- sponding lesions. Recently, many studies find that hyperuricemia is closely related with the progression of diabetes mellitus. Hyperuricemia is an independent risk factor resulting in kidney disfunction in patients with type 2 diabetes mellitus (T2DM). The present paper aims to review the relationship among the level of serum uric acid ，the disorder of glycometabolic and diabetic nephropathy (DN) in patients with type 2 diabetes mellitus. 【Key words 】 Type 2 diabetes mellitus; Serum uric acid; Glycometabolic disorder; Diabetic nephropathy 血尿酸(Serum uric acid ，SUA)是嘌呤代谢的最终 研究表明在普通人群、高血压人群及2 型糖尿病人群 [4-5]