瓜蒌薤白白酒汤螺甾皂苷类活性成分研究.pdf

( ) 药学学报 Acta Pharmaceutica Sinica 2003 ,38 6 :433 - 437 4·33 · 瓜蒌薤白白酒汤螺甾皂苷类活性成分研究 何祥久 , 王乃利 , 邱　峰 , 姚新生 (沈阳药科大学 天然药物化学教研室 , 辽宁 沈阳 110016) 摘要 : 目的 　研究瓜蒌薤白白酒汤作用的物质基础。方法 　在药理活性指导下利用各种化学和色谱手段对复 方进行追踪分离并鉴定其化学结构。结果 　从活性部位中分离得到 7 个活性螺甾类化合物。结论 　7 个化合物均 有抑制血小板聚集活性 ,其中化合物 5 和 6 的抑制活性最强。 关键词 : 瓜蒌薤白白酒汤 ; 活性成分 ; 螺甾类化合物 ; 抗血小板聚集活性 ( ) 中图分类号: R284. 1 ; R284. 2 　　　文献标识码 : A 　　　文章编号 : 0513 - 4870 2003 06 - 0433 - 05 Study on the active spirostanol saponins of Gualou xiebai baijiutang HE Xiangjiu , WANG Naili , QIU Feng , YAO Xinsheng ( ) School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang 110016 , China Abstract : Aim 　To study the basis of actions of Gualou xiebai baijiutang . Methods 　Guided by bioactivities , chemical and chromatographic ways were applied to isolate and purify the prescription. The chemical structures were identified by chemical and spectral ways. The activities on cardiovascular system of the pure compounds were measured. Results 　Seven steroidal compounds were isolated and identified from the active parts. Conclusion 　Compounds 5 and 6 showed good antiplatelet aggregation activities induced by ADP - 1 - 1 and PAF. The IC of