癫痫病新药（New drug for epilepsy）.doc

癫痫病新药（New drug for epilepsy） Epilepsy (Epilepsy) is a chronic disease of the brain that discharges abnormally and leads to recurrent brain dysfunction. Its incidence of disease is high, the disease course is long, and it has a great influence on family and society. The activity of ion channels is the basis of electrical excitability in the nervous system. Voltage dependent VGSCs channels (Voltage-gatedsodiumchannels) play an important role in the process of brain excitability, which is responsible for the generation and conduction of the action potential of neurons [1]. VGSCs dysfunction caused by ion channel disease is by far the most common channel disease in humans. It has been proved to be related to epilepsy, autism and migraine and many other nervous system diseases, [2]. The World Health Organization (WHO) estimates that more than 50 million people worldwide are suffering from epilepsy, [3]. Because VGSCs is an important target for the treatment of epilepsy, a large number of antiepileptic drugs such as C Masi Bing (CBZ), lamotrigine (LTG), by acting on VGSCs, to control the seizures in a certain extent. However, they have long been a large number of taking control of patients at the same time attack, there are certain toxic side effects, taking C Masi Bing on schedule, rash and other [4,5]. Therefore, the development of specific, strong, safe and well tolerated antiepileptic drugs meets the urgent needs of the majority of epilepsy patients. The use of traditional Chinese medicine has a long history. Some drugs have better antiepileptic effect and less toxic side effects in long-term applications, and have broad prospects for development. But compared to the monomer compounds identified as western medicine, at this stage, the majority of Chinese medicine is faced with complex composition, mechanism of action is not clear, the identity of the modern health concept is difficult to be standardized and scientific, it also limits the use and promotion of tradition