痛风100问（100 questions of gout）.doc

痛风100问（100 questions of gout） 81. what are the drugs that promote uric acid excretion? Uricosuric commonly used has the following three types: (1) probenecid (Bing Huangshu): childhood often dose, beginning with 0.25g 2 times a day, 0.5g increased to 3 times daily for two weeks, the maximum daily dose of not more than 2.0gg, about 5% of patients with skin rash, fever, gastrointestinal irritation, and renal colic provoke acute side effects. (2): sulphinpyrazone is phenylbutazone derivatives uricotelism than probenecid strong, side effects are also relatively large. There are side effects of transient rash, gastrointestinal reactions, nephrotoxicity, thrombocytopenia, and thrombocytopenia. (3) benzyl bromide (Malone): as a powerful diuretic, it has been used extensively in Europe for many years. Benzene bromine Malone 25 ~ 100mg, once a day, for primary gout, toxicity, does not affect the function of liver and kidney, rarely rash and fever, but gastrointestinal reaction, renal colic and trigger acute arthritis. 82. what are the drugs that inhibit uric acid synthesis? Up to now, only allopurinol has a rapid lowering of serum uric acid levels, inhibits the synthesis of gout stones and uric acid stones in the kidneys, and promotes dissolution of the gout stone. The dose of 100mg is 3 times a day, and can be increased to 200mg 3 times a day. Combined with uric acid drugs can enhance efficacy, but generally do not combine medication. The individual patient may have fever, allergic rash, abdominal pain, diarrhea, leukopenia and thrombocytopenia, even liver function damage and other side effects, drug withdrawal and give the corresponding treatment were recovered, occasional necrotizing dermatitis is a serious illness, treatment should be immediately. Metastatic gout attack may also occur during the treatment, and can be supplemented with colchicine, which is mostly used for secondary gout. 83., gout attack interval and chronic stage, is not just use allopurinol? During the