肝功能储备讲课（Lectures on hepatic function reserve）.docVIP

肝功能储备讲课（Lectures on hepatic function reserve） Clinical significance In patients with end-stage liver disease (HCC, cirrhosis, etc), hepatic cells are destroyed seriously, the reserve function is impaired, and infection, surgery, drugs and other effects may lead to liver failure and death. Therefore, the accurate assessment of hepatic reserve function is of great significance in predicting the risk of operation, selecting proper treatment methods, reducing the mortality rate and postoperative complications ICG principle, ICG (Indocyanine Green for Injection), our hospital uses ICG reagent made in China (produced by Dandong Liaoning Pharmaceutical Co., Ltd.), 25 mg/ branch, DDG 3300K analyzer (made by Japan opto Electronics Co., Ltd.). Dissolve the ICG reagent and dilute it to 5 mg/ml. The patients with supine position, at a dose of 0.5 mg/kg from the elbow vein injection. The nasal clamp probe equipped with DDG 3300K was continuously tested for ICG concentration in the blood. ICG does not have intestinal circulation, biotransformation, no lymph reflux, no renal metabolism, no toxic side effects. Because of the above characteristics, ICG has become the most ideal pigment for detecting hepatic reserve function. The ICG test is the most common test for evaluating hepatic reserve function. Used to diagnose liver cirrhosis, liver fibrosis, ductile hepatitis, occupational and drug induced liver diseases, to understand the extent of liver damage and reserve function. The clinical application has the advantages of quickness, simplicity, safety, accuracy, slight trauma and so on. The hepatic circulation: the process by which drugs excreted by the liver enter the intestine and enter the body again with bile. Drugs with an intestinal circulation usually function longer. Biotransformation: refers to exogenous chemicals in the body through a variety of enzymes catalyzed metabolic transformation. Biotransformation is an important part of the organisms disposal of exogenous chemica