胃溃疡药物治疗（Gastric ulcer, drug therapy）.docVIP

胃溃疡药物治疗（Gastric ulcer, drug therapy） Medication (1) H2 receptor antagonist: it is the main medicine for the treatment of ulcer disease, and it has better therapeutic effect on DU. (Simiti Martin, Rene Titi) by cimetidine, famotidine and other drug treatment. Cimetidine common usage: 200mg, 3 times a day, 400mg before then serving 4 weeks; the healing rate was 70%~80%, 8 weeks is almost 100%, given 800mg/d maintenance dose within one year, the recurrence rate was 44%, such as after the ulcer healing to maintain the amount of prevention of recurrence within a year, the recurrence rate of 50%. The commonly used method of ranitidine was 150mg, 2 times a day, after healing given a maintenance dose of 150mg every night before bed clothes again; 4 weeks ulcer healing rate was 50%~90%, 8 weeks for the 83%~93% application, maintenance dose a year recurrence rate is about 35%. The use of famotidine was 20mg, taking 2 or 40mg pills per night before going to bed. The efficacy was similar to that of ranitidine. (2) H+-K+ATP enzyme (proton pump) inhibitors: Omeprazole (Ake) as the representative, is the latest and most powerful acid inhibiting drugs, and has mucosal protection and anti Helicobacter pylori role. Omeprazole in the treatment of peptic ulcer, not only can quickly relieve the symptoms of active ulcers, accelerate ulcer healing, but also in long-term treatment has a reliable role in maintaining healing. Daily use of 20~60mg omeprazole, about 64% of patients after 2 weeks of treatment, symptoms disappeared, ulcers healed. Compared with the H2 receptor antagonist, omeprazole showed a faster effect on pain relief and a higher rate of ulcer healing. (3) anti Helicobacter pylori (Hp) treatment: the main inhibiting or killing effects of Hp are bismuth, metronidazole or tinidazole, amoxicillin, clarithromycin, tetracycline, furazolidone and so on. Killing Hp can improve the curative effect and prevent the recurrence. However, there is no single drug can effectively eradicate