酶工程第8章（Enzyme engineering eighth chapters）.docVIP

酶工程第8章（Enzyme engineering eighth chapters） The eighth chapter is the application of enzyme The application of the enzyme is one of the main content of enzyme engineering. 1. Application of enzymes in medicine Enzymes are widely used in medicine, and can be summarized into the following 3 aspects: (1) diagnose the disease with enzyme (2) the treatment of diseases with enzymes (3) make all kinds of drugs with enzymes Application of 1.1 enzymes in disease diagnosis (1) diagnose the disease according to the change of enzyme activity in vivo: Table 9-1 disease diagnosis by enzyme activity changes Enzyme disease and enzyme activity change Amylase, pancreatic disease, elevated kidney disease, decreased liver disease Cholinesterase, liver disease, cirrhosis, organophosphorus poisoning, rheumatism and so on, decreased vitality Acid phosphatase, prostate cancer, hepatitis, and red blood cell lesions increased activity Alkaline phosphatase, rickets, cartilage disease, osteoma, hyperparathyroidism, increased vitality, cartilage dysplasia, decreased vitality Alanine aminotransferase, liver disease, myocardial infarction and other activities increased Aspartate aminotransferase liver disease, myocardial infarction, increase vitality Gamma glutamyl aminopeptidase (-GT), primary and secondary liver cancer, increased the activity to more than 200 units, and the activity of serum enzyme increased in obstructive jaundice, liver cirrhosis, biliary tract cancer and so on Aldolase acute infectious hepatitis, myocardial infarction, enzyme activity in serum increased significantly Arginine lyase, acute and chronic hepatitis, increased serum enzyme activity Pepsin, gastric cancer, increased vitality, duodenal ulcer, decreased vitality Phosphorylation of zinc phosphate, hepatitis, cancer, increased vitality Aldolase beta glucose renal and bladder cancer, increase vitality Carbonic anhydrase activity increased scurvy, anemia and so on. Lactic dehydrogenase, liver cancer, acute hepatitis, myoc