钙拮抗剂（Calcium antagonists）.doc

钙拮抗剂（Calcium antagonists） The fifteenth chapter is calcium antagonist Section 1 Classification and drug name of calcium antagonists [assistant does not require] Selective calcium antagonists (I) Vera Pammy, paraffin. (zy2003-1-222) (two) two dihydropyridine, nifedipine, nimodipine, nitrendipine and amlodipine. (three) diltiazem and diltiazem. Two 、 non selective calcium antagonists (a) two benzene piperazine flunarizine and cinnarizine. (two) class prenylamine prenylamine. (three) other classes of methylphenidate. The following is zy2003-1-222. Phenylalkylamine calcium antagonist is the selective The A. of nifedipine The B. of verapamil Prenylamine * C. D. perhexilin The E. of flunarizine Answer: B The pharmacological action and clinical application of second calcium antagonists I. pharmacological effects (I) myocardium 1. the negative inotropic effect of calcium antagonists can reduce the content of Ca2+ in myocardial cells, causing negative inotropic effect, can make the myocardial oxygen consumption is reduced, and the drug induced vasodilation, the cardiac afterload decreased, the myocardial oxygen consumption decreased further. 2. negative chronotropic and dromotropic slow response cells such as sinoatrial node and atrioventricular node 0 phase and 4 phase pole automatic slow depolarization and Ca2+ influx. The 0 phase of polarization and conduction, and the 4 phase automatic depolarization and self. Calcium antagonists could inhibit the Ca2+ flow in the above cases. It can cause negative frequency and negative conduction, such as slow conduction of atrioventricular node, prolongation of refractory period, reentry and excitement. It can be used to treat paroxysmal supraventricular tachycardia. Calcium antagonists can reduce the automaticity of the sinoatrial node and slow the heart rate. 3. myocardial ischemia protection, myocardial ischemia, sodium pump and calcium pump inhibited and calcium passive transport to strengthen, can make intracellular calcium acc