雌激素与高血脂的关系在妇女冠心病发病中的作用（The role of estrogen and hyperlipidemia in the pathogenesis of coronary heart disease in women）.docVIP

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雌激素与高血脂的关系在妇女冠心病发病中的作用（The role of estrogen and hyperlipidemia in the pathogenesis of coronary heart disease in women）.doc

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雌激素与高血脂的关系在妇女冠心病发病中的作用（The role of estrogen and hyperlipidemia in the pathogenesis of coronary heart disease in women）

雌激素与高血脂的关系在妇女冠心病发病中的作用（The role of estrogen and hyperlipidemia in the pathogenesis of coronary heart disease in women） The role of estrogen and hyperlipidemia in the pathogenesis of coronary heart disease in women Coronary heart disease (CHD) is the leading cause of death in humans and the incidence of coronary heart disease in postmenopausal women And mortality rates rose significantly. The main reason for the increase is dyslipidemia (CHD). Epidemiological data showed crown The incidence of heart disease was positively related to serum cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels, Negatively related to high-density lipoprotein cholesterol (HDL-C) levels. Whereas the level of glycerol three (TG) increased only Increase coronary heart disease in women. Postmenopausal women with estrogen replacement therapy (ERT) take more small doses of E. Generally believe, Both estradiol estradiol (EE2), bound estrogen (CEE) and natural estrogen (17- beta E2) have both elevated HDL-C and lower levels The role of low LDL-C. Because the long-term use of E alone can lead to endometrial hyperplasia and increase the incidence of endometrial cancer. Therefore, the combination therapy of E-P is now adopted. ERT can reduce mortality and prolong life in postmenopausal women. Keywords coronary heart disease; postmenopausal women; First, the relationship between CHD and dyslipidemia Epidemiological data show that the incidence of coronary heart disease is positively related to serum cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels, and negatively related to high-density lipoprotein cholesterol (HDL-C) levels. The increase in glycerol three (TG) levels only increased coronary heart disease in women. Prospective study of Framingham region for 30 years showed that TC and LDL-C increased by 1%, CHD increased 2%, LDL-C, 3.9mnol / L (150mg / dl) and TC / HDL-C 4.5 is the high risk factors of CHD, while HDL-C decreased [1 independent risk factors o