驱虫药致迟发性脑病的药物暴露与发病因素（Drug exposure and pathogenic factors in delayed encephalopathy caused by anthelmintic）.docVIP

驱虫药致迟发性脑病的药物暴露与发病因素（Drug exposure and pathogenic factors in delayed encephalopathy caused by anthelmintic） Drug exposure and pathogenic factors in delayed encephalopathy caused by anthelmintic 2011-04-03 Zheng Rongyuan In the past 20 years, the anthelmintic drugs have been listed in China, and their adverse reactions have been gradually recognized, The late adverse reactions, especially the severe impairment of the central nervous system, have not received widespread attention, although they have been reported in a case study Reports continue to show, but clinical missed cases are still rare. Analysis of 114 cases of delayed onset of imidazole anthelmintic The drug exposure of encephalopathy, and then speculate on the pathogenesis and possible pathogenesis of the disease. I. data and methods The data of this group were taken from the archives of encephalitis specific diseases, and the diagnostic criteria of the disease were reviewed. [1], 45 of the reported cases were no longer counted; those who lacked the certification basis were excluded; only the history of drug exposure was included And the certification is based on confirmed cases; the case data of pediatrics is incomplete; the diagnosis is easy to be confused and not accepted. Two, results and analysis 1. drug exposure: in this group, 114 cases took four imidazole, 36 cases (31.6%), second place (1982 four imidazole was listed as the Ministry of health, the elimination of drugs) brand names include tetramizole and ascaridole Dan (pill). Taking prescription Methods: take 6 tablets (or 50 pills) each night and morning, and some take 6 tablets (or 50 pills) at night before going to bed or on the morning empty stomach, Take 2~3 days, total 150~450 mg; take levamisole 68 cases (59.6%), ranking first (1983) After replacing four, imidazole) brand names include levamisole, levamisole hydrochloride tablets, tablets and new anthelmintic effects and hook Dan etc., The dosage, dosage and total amount were the same as tho