抗肿瘤动物类中药的研究进展.PDF

PROGRESS IN PHARMACEUTICAL SCIENCES 2014,38 6 :432-437 432 ( ) 抗肿瘤动物类中药的研究进展 王祥，徐寒梅 * （中国药科大学生命科学与技术学院，江苏 南京 210009） [ 摘要 ] 动物类中药资源丰富，其在肿瘤治疗中取得的疗效引起医药领域广泛关注，已成为抗肿瘤药物的一个新的研究热点。然而，抗肿瘤 动物类中药成分复杂，其有效成分和作用机制尚有待进一步明确。综述常用抗肿瘤动物类中药及其活性成分、抗肿瘤动物类中药作用机制 与临床应用，以期为抗肿瘤动物类中药的深入研究与开发提供参考。 [ 关键词 ] 动物类中药；抗肿瘤活性；有效成分；作用机制；临床应用 [ 中图分类号 ] R282.74 [ 文献标志码 ] A [ 文章编号 ] 1001-5094（2014）06-0432-06 Research Progress in Antitumor Traditional Chinese Medicines of Animal Origin WANG Xiang, XU Hanmei ( School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China) [Abstract] Traditional Chinese medicines of animal origin have plentiful resources, which have attracted extensive attention in the domain of medicine owing to their antitumor efficacies and become a new hotspot of antitumor drug research. However, the antitumor traditional Chinese medicines of animal origin have complex components and their active components and mechanisms of action remains to be further defined. The common antitumor traditional Chinese medicines of animal origin and their active components as well as the mechanisms of action and clinical applications of antitumor traditional Chinese medicines of animal origin were reviewed so as to provide the reference for the further research and development of traditional Chinese medicines. [Key words] traditional Chinese medicines of animal origin; antitumor activity; active ingredient; mechanism of action; clinical application 我国幅员辽阔、物产丰富，盛产许多具有药用价值 泌的一种白色乳状液体，其抗肿瘤活性成分主要是蟾 的动物。动物类中药在疾病治疗中的应用在我国有着 蜍二烯羟酸内酯和吲哚生物碱，蟾蜍二烯羟酸内酯能