naloxone treatment of severe traumatic brain injury（纳洛酮治疗重度创伤性脑损伤）.docVIP

Naloxone treatment of severe traumatic brain injury [Keywords:] naloxone [Keywords:] Naloxone, traumatic brain injury With the improvement of the deepening of craniocerebral injury in basic research and clinical diagnosis and treatment of severe traumatic brain injury treatment success rate significantly improved, but mortality was still 25% [1] in our hospital from January 2001 - 2003 were treated 238 cases of severe traumatic brain injury (17 cases who died within 6 h of admission, except on the basis of conventional therapy, treatment with naloxone to good effect, are summarized below. (1) clinical data 1.1 General information on male 182 cases, 56 cases of women aged 9 to 76 years, the average age of 41.5 years. Causes of injury: traffic accident in 222 cases, 12 cases of fall injury, combat injury four cases. 1.2 The main clinical manifestations of all patients admitted to hospital in a coma GCS 3 to 5 points and 144 cases (60.5%, 6 to 8 minutes and 94 cases (39.5%), showing herniation in 146 cases (61.3%, combined liver and splenic rupture 3 cases of pelvic fracture in two cases. See epidural hematoma of 1.3 on admission CT scan in 36 cases (15.1%, 124 cases (51.8% subdural hematoma, brain contusion alone in 44 cases (18.4%, primary brain stem injury in 18 cases (7.5%, 16 cases of intracerebral and intraventricular hematoma (6.6% of all patients had varying degrees of midline shift, ventricular compression, the basal cistern. 1.4 The treatment of this group of patients on admission underwent emergency craniotomy in 182 cases (76.5%, including intracranial hematoma and / or decompressive craniectomy conservative treatment in 56 cases (23.5%, including primary brain stem injury or coma, shallow, no herniation. all patients within 6 h after admission, naloxone 3.2 mg add 5% GS 500 ml of intravenous continuous application of four weeks. 2 Results Patients in this group of 238 cases, 54 cases of death occurred at 2 week