烟酸缓释微丸的研究.pdfVIP

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  • 2017-09-03 发布于江苏
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of 8/24mesh about90%.Theresults yieldobjectivepellets(1 cut)was suggested the andtheformulationofNicotinicacid can preparationprocess pellets reachthe expectgoals. Afluid—bed was forthe ofthe sprayprocessoradoptedcoatingpellets.The formula of NE30Dto the coating composed Eudragit prepare sustained—releaseandthe of non-pn·dependent pellets(T2) combination formula of NE30Dand to L30D一55 coating composedEudragit Eudragit the sustained-releasewerestudiedand preparepH—dependent pellets(T0 contrasted.Theinfluenceonthereleaseof of factors differentformula coating Nicotinicacid were and formulation of pelletsinvestigated,The technology different formulawere resultsdemonstratedthattwo coating optimized.The kindsofcoated showed sustain-releasethe obviously effect,and pellets drug release invitrofollowedfirst-orderkinetics. profiles IP—HPLCmethodWaS todetecttheconcentrationofNicotinic performed insix were acidin concentrationofNicotinicacid p

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