急性低氧大鼠视网膜突触改变及牛磺酸的影响研究-第三军医大学学报.DOC

文章编号：200806002 牛磺酸对急性低氧大鼠视网膜内网状层损伤的防护效应 陈 卡，糜漫天，陈 芳，许红霞，曾凯宏，张亚洁（第三军医大学军事预防医学院营养与食品卫生学教研室重庆市营养与食品安全重点实验室Protective effects of taurine on inner plexiform layer of retina in rats exposed to hypobaric hypoxia CHEN Ka,MI Man-tian,CHEN Fang，XU Hong-xia,ZENG Kai-hong,ZHANG Ya-jie（Department of Nutrition and Food Hygiene,College of Preventive Medicine,Third Military Medical University; Key Laboratory of Nutrition and Food Safety of Chongqing,Chongqing，400038,China） Abstract：Objectivetransmission electron microscope and the average density of Synapsin (SYS) was determined through immunohistofluorescence method. Results Prolonged latence and lower amplitude were detected in rats exposed to 1 or 3 days’ hypobaric hypoxia of both NH and TH group, and relative normal OPs were measured in rats exposed to 7days’ hypoxia. Compared with the same defined hypoxia point of NH group, the amplitudes of OS2 were all greater (p0.05), and the latence of OS2 of rats exposed to 3 days’ hypoxia was shorter (p0.05).Swollen or cavitary mitochondrias in axon, disintegrated dendritical microtube, scarce synapses with depleted vesicle were observed in IPL of rats in NH group, while distinct synapses with abundant vesicles were observed in TH group.Synapsin was mainly distributed in IPL of every group.Compared with NC group, the density of 基金项目：全军“十一五”专项资助项目（062028）;重庆市营养与食品安全重点实验室开放课题(2007) ;第三军医大学科研创新基金（2007XG19） Supported by the Foundation of the “Eleventh Five-year Plan ” for Medical Science Development of PLA (062028)，Free courses of Key Laboratory of Nutrition and Food Safety of Chongqing(2007)，The Foundation of the Innovative Scientific Research of Third Military Medical University (2007XG19). 作者简介：陈 卡，女，四川邻水人，博士研究生，主要从事营养与视功能研究。电话：(023E-mail:chen_ka@ 通信作者：糜漫天，电话：（023收稿日期：2008-06-02；修回日期：2008-06-25 synapsin decreased in rats exposed to 1 or 3 days’ hypoxia in both groups(p0.05). But in TH1d group, the synapsin density was significantly higher than the NH1d group (p0.05)