acute myocardial infarction bone marrow and peripheral blood cardiac transcription factors nkx2-5（急性心肌梗死心脏转录因子nkx2-5骨髓和外周血）.docVIP

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acute myocardial infarction bone marrow and peripheral blood cardiac transcription factors nkx2-5（急性心肌梗死心脏转录因子nkx2-5骨髓和外周血）.doc

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acute myocardial infarction bone marrow and peripheral blood cardiac transcription factors nkx2-5（急性心肌梗死心脏转录因子nkx2-5骨髓和外周血）

Acute myocardial infarction bone marrow and peripheral blood cardiac transcription factors Nkx2-5 Author: Xu Zhiwei Xu Xia Zhang Zhongming Red endothelial [Keywords] myocardial infarction; monocytes; Nkx2-5 Abstract: Objective To observe the mice myocardial infarction, bone marrow and peripheral blood mononuclear cells of cardiac-specific transcription factor Nkx2-5 change method with a large dose of isoproterenol (10mg.kg continuous injection three days caused myocardial acute shortage of mice model of hemorrhagic infarction, 30 min after injection of the three days, by enucleation method peripheral blood, separating the posterior limbs of the femur, tibia, a bone marrow fluid flushing the marrow cavity, bone marrow and peripheral blood mononuclear cells isolated by density gradient centrifugation, the normal group with myocardial ischemia and infarction. cells Western blotting analysis, relatively normal group and myocardial infarction, bone marrow and peripheral blood mononuclear cells Center changes of muscle-specific transcription factor Nkx2-5 results in normal bone marrow mononuclear cells Nkx2-5 expression of normal peripheral blood mononuclear cells Nkx2-5 expression; myocardial infarction, bone marrow and peripheral blood Nkx2-5 expression was significantly increased compared with the normal group significant (P lt;0.05) conclusion in normal bone marrow without culture or induce i.e. presence monocytes Nkx2-5 expression increased after acute myocardial infarction, peripheral blood mobilization. Keywords: myocardial infarction; monocytes; Nkx2-5 Abstract: Objective To examine the cardiac specific transcription factor Nkx2-5in the bone marrow and peripheral blood after myocardial infarction.Methods The mouse model of myocardial infarction was formed by sequential injection of large dose Iso (10mg.kgfor3days.Bone marrow and peripheral blood mononuclear cells (PBMCwere then collected from the model and the normal control mice to compare the e