acute phase plasma and brain tissue content of insulin-like growth factor-1 on experimental cerebral hemorrhage（急性期血浆和脑组织内容的胰岛素样生长因子- 1在实验性脑出血）.docVIP

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acute phase plasma and brain tissue content of insulin-like growth factor-1 on experimental cerebral hemorrhage（急性期血浆和脑组织内容的胰岛素样生长因子- 1在实验性脑出血）.doc

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acute phase plasma and brain tissue content of insulin-like growth factor-1 on experimental cerebral hemorrhage（急性期血浆和脑组织内容的胰岛素样生长因子- 1在实验性脑出血）

Acute phase plasma and brain tissue content of insulin-like growth factor-1 on experimental cerebral hemorrhage Author: Lvyun Li Fu Xuefeng Road Kui Liu Jun Xu Wenwu [Keywords] rats Keywords: rat; cerebral hemorrhage; insulin-like growth factor-1; brain tissue; plasma Abstract: Objective To investigate the insulin-like growth factor -1 (IGF-1 levels in the acute phase of experimental cerebral hemorrhage in rats plasma and brain tissue changes clarify the role in the process of cerebral hemorrhage 80 Methods SD rats were randomly divided into control group, a small amount of cerebral hemorrhage group, in the amount of cerebral hemorrhage group and a large number of brain hemorrhage group, n = 20, n = 1,8,24,48 and 72 h after the hemorrhage were divided into five groups, each group of four. using Nath rat cerebral hemorrhage model, the content of plasma and brain tissue IGF-1 was measured by radioimmunoassay. compared with the control group, large, medium, small amount of cerebral hemorrhage in cerebral hemorrhage, the 1h plasma IGF- 1 began to reduce, but no significant difference, 8, 24 and 48h decreased significantly (P lt;0.01, dropped the most obvious to 8h, 72h has been restored to 1h level, compared with the control group, cerebral hemorrhage, 8, 24 and 48h perihematoma organization IGF-1 were significantly increased (P lt;0.01,8 h peak, then gradually decreased to close to the control group, 72h., in a small amount of cerebral hemorrhage group in 8,24 and 48 h as compared There are very significant difference (P lt;0.01. conclusions of IGF-1 may be involved in the pathophysiological process of cerebral hemorrhage, a new factor. Keywords: rat; cerebral hemorrhage; insulin-like growth factor-1; perihemotoma; plasma Abstract: AIM To observe insulin-like growth factor-1 (IGF-1concentration change in plasma perihemotoma of rats with acute cerebral hemorrhage in order to explore the effect of IGF-1on acute cerebral hemorrhage.METHODS Eighty SD rats w