analysis of anti-atherosclerotic role of carvedilol（分析anti-atherosclerotic卡维地洛的角色）.docVIP

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2017-09-05 发布于浙江
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analysis of anti-atherosclerotic role of carvedilol（分析anti-atherosclerotic卡维地洛的角色）.doc

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analysis of anti-atherosclerotic role of carvedilol（分析anti-atherosclerotic卡维地洛的角色）

Analysis of anti-atherosclerotic role of carvedilol Paper to write network: [Abstract] Objective To investigate the activation of the antioxidant effects of carvedilol in atherosclerotic lesions and proliferating cell nuclear antigen (PCNA and nuclear factor kappaBp65 (NFκBp65. Of male New Zealand white rabbits 24 were randomly divided the normal group, high-fat group, carvedilol carvedilol group (n = 8), for a total diet for 10 weeks after the end of the experiment, enzymatic detection of serum triglyceride and cholesterol in rabbits, xanthine oxidase serum ultra- superoxide dismutase (SOD, thiobarbituric acid colorimetric assay of malondialdehyde (MDA, and the method of immunohistochemical determination of the expression of the vascular wall of PCNA and NFκBp65 results of high-fat group and the carvedilol group serum triglyceride and cholesterol than the normal group was significantly increased (F = 146.25,287.83, q = 14.76 ~ 20.75, P lt;0.01, the difference between the two groups was not statistically significant (q = 0.53,0.59, Pgt; 0.05. fat group than in the normal group, SOD significantly reduced, MDA increased significantly, while in the carvedilol group a higher fat, SOD was increased, MDA decreased (F = 21.65,75.64, q = 4.98 ~ 24.29, P lt;0.01). . high-fat group PCNA and NFκBp65 in expression significantly increased compared with normal group, the carvedilol group of PCNA and NFκBp65 expression of the higher fat group was significantly reduced (F = 426.12,521.38, q = 56.15 ~ 75.87, P lt;0.01.PCNA NFκBp65 the positive correlation (r = 0.975, P lt;0.01. Conclusion Carvedilol reduce the lipid oxidative damage may be the blocking of NFκB activation, thereby inhibiting the proliferation of smooth muscle cells. [Keywords:] arteriosclerosis carvedilol antioxidant cell proliferation in rabbit [ABSTRACT] ObjectiveTo study the effect of carvedilol on anti  oxidation and activation of PCAN and NFκB on atherosclerosis.MethodsTwenty four male New Zealand wh