analysis of the progress of hyperthyroidism induced skeletal muscle lesions（分析甲状腺机能亢进引起的骨骼肌病变的进展）.doc

Analysis of the progress of hyperthyroidism induced skeletal muscle lesions Papers to write network: [Keywords] thyroid Skeletal muscle and motor endplate integrity of the structure and the function of coordination is to ensure that the basis of skeletal muscle to complete the fine activities. Changes in hormone levels can have some impact on the nervous dominated muscles, thereby causing pathological changes. Thyroid dysfunction led to excessively high or low levels of thyroid hormone in the body, can cause skeletal muscle cytopathic, causing respiratory muscles, limb muscle and cardiac physiological function and biochemical metabolic changes, leading to the occurrence of the corresponding disease. The main clinical manifestations of a thyroid hyperfunction (hyperthyroidism induced skeletal muscle lesions Hyperthyroidism is a common clinical endocrine disease can affect multiple body systems, and the corresponding clinical manifestations mainly to increased food intake, body weight loss, palpitations, sweating, irritability, including lesions known as hyperthyroidism involving the muscles and appear hyperthyroid myopathy is generally hyperthyroid myopathy is divided into 5 categories [1 to 4]: ① acute thyrotoxic myopathy (ATM) ② chronic thyrotoxic myopathy (CTM), ③ thyrotoxic periodic paralysis (TPP) The ④ hyperthyroid myasthenia gravis, the ⑤ hyperthyroid extraocular muscle paralysis .5 class myopathy CTM most common, followed by TPP, ATM is the most rare but dangerous disease, high mortality [5]. Hyperthyroid myopathy of skeletal muscle and its motor endplate changes 2.1 hyperthyroidism induced skeletal muscle lesions muscle electromyography (EMG and The abnormal EMG myopathy signs and symptoms, pathological changes in patients with hyperthyroidism. EMG change is mainly characterized by myogenic damage, motor unit potential duration shortened its most common manifestation, followed to reduce volatility, multiphase potential increase, rare fasci