g蛋白藕联（G protein coupling）.docVIP

g蛋白藕联（G protein coupling） Most of the cytoplasmic membrane, signal transduction system is the most important signal transduction mediated by G- protein. The signal transduction system has two important characteristics: the system consists of three parts: 7 transmembrane receptors, G proteins and effectors (enzyme); the second messenger. The structure and function of the 1 G protein G protein, GTP binding protein (GTP binding protein), a variety of life activities of cells, such as cell communication, ribosome and endoplasmic reticulum binding, vesicular transport, microtubule assembly and protein synthesis. - heterotrimeric G protein (heterotrimeric G protein) structure G protein coupled system of heterotrimeric G protein is composed of three different subunits, three subunits are alpha, beta, gamma, the total molecular weight of about 100kDa. The G protein has a variety of regulatory function, including Gs and Gi on adenylate cyclase activation and inhibition of cGMP phosphodiesterase activity regulation, regulation of phospholipase C, intracellular Ca2+ concentration regulation, in addition to participate in the regulation of gated ion channels. Nuclear function - protein kinase A: regulation of gene expression Activated by cAMP PKA, most in the cytosol activates some cytoplasmic protein targets, there are a few activated PKA can be transferred to the nucleus in the phosphorylation of some important nuclear protein, most of which is called CREB (cAMP response element binding, cAMP element binding transcription factor) factor G (G protein cycle) protein cycle The G protein coupled signal transduction system, G protein to two different state in the cytoplasmic membrane. A resting state, namely three state; the other is the active state of G protein changed from non active state into active state, and then return to the process of the non active state is called the transformation of the active G protein cycle G protein associated with three proteins: GTPase - activat