埃索美拉唑对胃溃疡患者多项血清因子影响探究.docVIP

埃索美拉唑对胃溃疡患者多项血清因子影响探究[摘要] 目的：探讨埃索美拉唑对胃溃疡患者多项血清因子的影响。方法：选取2008年1月～2010年11月于本院进行治疗的60例胃溃疡患者为研究对象，将其随机分为A组（埃索美拉唑组）30例和B组（奥美拉唑组）30例，同时选取同期的30例健康人员为C组，后将三组人员的血清IL-2、IL-6、MTL及PYY水平进行统计及比较。结果：经研究发现，治疗后A组及C组的血清IL-2均高于B组，而血清IL-6、MTL及PYY水平则低于B组，P＜0.05或P＜0.01，差异有统计学意义或差异有显著统计学意义。结论：埃索美拉唑对胃溃疡患者多项血清因子的影响较奥美拉唑要好，值得推广应用。 [关键词] 埃索美拉唑；奥美拉唑；胃溃疡；多项血清因子；影响 [中图分类号] R573.1 [文献标识码]A[文章编号]1674-4721（2011）04（b）-034-02 The study on the influence of esomeprazole for various serum factors of the patients with gastric ulcer CHEN Weimin, JIANG Guorong The First People′s Hospital of Foshan City, Guangdong Province, Foshan 528000, China [Abstract] Objective: To study the influence of esomeprazole for various serum factors of the patients with gastric ulcer. Methods: 60 patients with gastric ulcer in our hospital from January 2008 to November 2010 were selected as research object, then they were randomly divided into group A (esomeprazolegroup) 30 cases and group B (omeprazolegroup) 30 cases, and 30 healthy peoples at the same time were selected as group C, then the serum IL-2, IL-6, MTL and PYYof the three groups were detected and compared. Results: According the results, the serum IL-2 of group A and group C were higher than those of group B, the serum IL-6, MTL and PYY were lower than those of group B, P＜0.05 or P＜0.01, there were significant or very significant differences. Conclusion: The influence of esomeprazole for various serum factors of the patients with gastric ulcer is bigger than omeprazole, and it is worthy of extension and application. [Key words] Esomeprazole; Omeprazole; Gastric ulcer; Various serum factors; Influence 胃溃疡为消化道疾病的一种，疾病的发展过程中，患者血清中的多项因子也随之发生变化，可从一定程度上反映疾病的发展及转归[1]。当采用药物进行治疗时患者的血清因子变化也可以从一个侧面反映药物的治疗效果。本文中笔者就埃索美拉唑对胃溃疡患者多项血清因子的影响进行研究，现将结果总结报道如下： 1 资料与方法 1.1 一般资料 选取2008年1月～2010年11月于本院进行治疗的60例胃溃疡患者为研究对象，将其随机分为A组（埃索美拉唑组）30例和B组（奥美拉唑组）30例，同时选取同期的30例健康人员为C组。A组的30例患者中，男性18例，女性12例，年龄29～72岁，平均（45.1±3.3）岁，病程0.6～3.6年，平均病程（2.5±0.6）年，溃疡大小0.8～1.9 cm，平均