哮喘CC16表达与糖皮质激素和白三烯受体拮抗剂影响地实验研究.pdfVIP

哮喘CCl6表达及糖皮质激素和白三烯受体拮抗剂影响的实验研究 英文摘要 TheEffectofBudesonideandMonkeluston of Expression Clara 1 Asthmatic Cell Protein(CC Mice Secretory 6)in Abstract objective： To the in and Claracell theblood tissue secretory investigate proteinexpression lung ofasthmaticmiceandthe and on 1 effectofbudesonidemonkelustCC6 to expression，and itsroleinasthma analyze pathogenesis． Methods： 96BALB／Cmiceweredividedintofour isasthmamodel is groups．A group，B BudesonideisMonlukast is control micewere group，C group，Dnegative group．All sensitized ofO．5ml 1 ovalbumin actively byintraperitonealinjection liquid(including00ug and 0and 7 D 14to 21the 400ug AI(OH)3)onday dayexceptgroup，Fromday day sensitizedmicewere allaerosol dilutedinsterile challenged州movalbumin(1％w／v for30minutes．TheC were physiologicalsaline)daily group given onehourafter for4 B were to weeks，111e antigenchallengedaily group exposed Budesonide Budesonide2ml NS 30minutesonehourafter suspl(including and 3m1)for