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a new geldanamycin analogue from streptomyces hygroscopicus一个新的geldanamycin模拟从链霉菌属hygroscopicus.pdf

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a new geldanamycin analogue from streptomyces hygroscopicus一个新的geldanamycin模拟从链霉菌属hygroscopicus

Molecules 2010, 15, 1161-1167; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Communication A New Geldanamycin Analogue from Streptomyces hygroscopicus Hao Zhang 1, Guang-Zhi Sun 2, Xiang Li 3, Hong-Yu Pan 3,* and Yan-Sheng Zhang 4,* 1 School of Resources and Environment, Jilin Agricultural University, Changchun, 130118, China; E-Mail: haozhang100@163.com (H.Z.) 2 Institute of Agricultural Modernization, Jilin Agricultural University, Changchun, 130118, China; E-Mail: gzsun1967@ (G.-Z.S.) 3 College of Plant Science, Jilin University, Changchun, 130062, China; E-Mail: drxiang@ (X.L.) 4 Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan, 430074, China; * Authors to whom correspondence should be addressed; E-Mails: zhangys@ (Y.-S.Z.); panhongyu@ (H-Y.P.). Received: 5 January 2010; in revised form: 10 February 2010 / Accepted: 2 March 2010 / Published: 3 March 2010 Abstract: A new geldanamycin analogue was isolated from Streptomyces hygroscopicus A070101. The structure was elucidated as 11-methoxy-17-formyl-17-demethoxy-18-O-21- O-dihydrogeldanamycin (1) on the basis of extensive 1D and 2D NMR as well as HRESI- MS spectroscopic data analysis. Compound 1 showed considerable cytotoxicity (SRB) against human cancer cell lines (breast cancer MCF-7, skin melanoma SK-MEL-2 and lung carcinoma COR-L23). Keywords: Streptomyces hygroscopicus; 11-methoxy-17-formyl-17-demethoxy-18-O-21- O-dihydrogeldanamycin; geldanamycin Molecules 2010, 15