a new triterpene from the plant of uncaria macrophylla一个新三萜烯钩藤属植物的macrophylla.pdfVIP

Molecules 2012, 17, 504-510; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article A New Triterpene from the Plant of Uncaria Macrophylla Guangli Sun 1,2, Xiaopo Zhang 1, Xudong Xu 1,*, Junshan Yang 1, Mingliang Zhong 1 and Jingquan Yuan 1,3 1 Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences Peking Union Medical College, Beijing 100193, China; E-Mail: guanglisun@126.com (G.S.); xiaopozhang2011@126.com (X.Z.); junshanyang@ (J.Y.); mingliangzhongsky@163.com (M.Z.); yjqgx@163.com (J.Y.) 2 Department of Pharmacy, School of Pharmacy, Hebei United University, Tangshan, Hebei 063000, China 3 Guangxi Institute of Medicinal Plant Development, Nanning, Guangxi 530023, China * Author to whom correspondence should be addressed; E-Mail: xdxu@; Tel./Fax: +86-010-5783-3296. Received: 27 November 2011; in revised form: 29 December 2011 / Accepted: 30 December 2011 / Published: 5 January 2012 Abstract: Our ongoing investigations on the stem bark of Uncaria macrophylla afforded a new ursolic triterpene, 3β,6β,19α-trihydroxy-urs-12-en-28-oic acid-24-carboxylic acid methyl ester (1), named uncariursanic acid, and three known ursolic triterpenes including 3β,6β,19α-trihydroxy-23-oxo-urs-12-en-28-oic acid (2), 3β,6β,19α-trihydroxy-urs-12-en- 28-oic acid (3) and ursolic acid (4). Their structures were elucidated by extensive spectral methods, including 1D and 2D NMR and HR-ESI-MS. The cytotoxicities of the four compounds were evaluated against two c