a proposal for identifying the low renal uric acid clearance phenotype建议识别低肾尿酸清除率表型.pdfVIP

Indraratna et al. Arthritis Research Therapy 2010, 12:149 /content/12/6/149 CO M M E N TA R Y A proposal for identifying the low renal uric acid clearance phenotype 1,2 3,4 1,2 1,2 5 Praveen L Indraratna , Sophie L Stocker , Kenneth M Williams , Garry G Graham , Graham Jones and Richard O Day*1,2 propose an amendment to the Simkin Index in order to Abstract focus upon abnormalities in renal tubular urate transport Investigation of the genetic basis of hyperuricaemia is causal for ‘under-excretion’ of urate. We suggest that a subject of intense interest. However, clinical studies renal uric acid clearance be normalised to the individual’s commonly include hyperuricaemic patients without GFR, as estimated by the creatinine clearance, to give the distinguishing between ‘over-producers’ or ‘under- fractional clearance of urate (FCU). FCU has been used excretors’ of urate. The statistical power of studies of in physiological studies but usually employing 24-hour genetic polymorphisms of genes encoding renal urate collections of urine [3,6]. We propose that FCU transporters is diluted if ‘over-producers’ of uric acid are calculated from spot urine samples be used as the included. We propose that lower than normal fractional inclusion criterion in studies examining the genetic basis renal clearance of urate is a better inclusion criterion for relatively low renal clearance of urate. A renal for these