a new saccharides and nnucleosides sensor based on tetrathiafulvalene-anthracene dyad with two boronic acid groups新糖类和nnucleosides传感器基于tetrathiafulvalene-anthracene二分体和两个boronic酸组.pdfVIP

Sensors 2006, 6, 954-961 sensors ISSN 1424-8220 © 2006 by MDPI /sensors A New Saccharides and Nnucleosides Sensor Based on Tetrathiafulvalene-anthracene Dyad with Two Boronic Acid Groups Wei Tan 1, 2, Zhuo Wang 1, 2, Deqing Zhang 1,* and Daoben Zhu 1 1 Beijing National Laboratory, Organic Solids Laboratory, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China 2 Graduate School of Chinese Academy of Science, Beijing 100080, China * Author to whom correspondence should be addressed. E-mail address: dqzhang@ Received: 30 April 2006 / Accepted: 17 July 2006 / Published: 24 August 2006 Abstract: A new saccharides sensor based on the TTF-anthracene dyad with two boronic acid (2) groups was designed and synthesized. This new saccharides sensor shows selectivity towards D-glucose while its analogue with one boronic acid group (1) was reported to bind D-Fructose selectively. Moreover, reaction of compound 2 with uridine induced even larger fluorescence enhancement under the same condition. Keywords: Saccharide, nucleoside, sensor, tetrathiafulvalene, boronic acid, fluorescence. 1. Introduction Fluorescent sensors with the ability to recognize various biologically important compounds are very useful for a wide range of application [1-4]. Much attention has been paid to the development of synthetic sensors for biologically important organic compounds such as neurotransmitters [5], amino acids [6], nucleotides [7] and carbohydrates [8-20]. Bo