a new role for the htlv-1 p8 protein increasing intercellular conduits and viral cell-to-cell transmission新角色htlv 1 p8蛋白增加细胞间导管和病毒细胞间传播.pdfVIP

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a new role for the htlv-1 p8 protein increasing intercellular conduits and viral cell-to-cell transmission新角色htlv 1 p8蛋白增加细胞间导管和病毒细胞间传播.pdf

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a new role for the htlv-1 p8 protein increasing intercellular conduits and viral cell-to-cell transmission新角色htlv 1 p8蛋白增加细胞间导管和病毒细胞间传播

Viruses 2011, 3, 254-259; doi:10.3390/v3030254 OPEN ACCESS viruses ISSN 1999-4915 /journal/viruses Commentary A New Role for the HTLV-1 p8 Protein: Increasing Intercellular Conduits and Viral Cell-to-Cell Transmission Marine Malbec †, Ferdinand Roesch † and Olivier Schwartz * Virus and Immunity Unit, Institut Pasteur, URA CNRS 3015, 28 rue du Dr. Roux, 75724 Paris, France † These authors contributed equally to this work. * Author to whom correspondence should be addressed; E-Mail: olivier.schwartz@pasteur.fr; Tel.: +33-145-688-353; Fax: +33-140-613-465. Received: 15 February 2011; in revised form: 2 March 2011 / Accepted: 2 March 2011 / Published: 9 March 2011 Abstract: Retroviruses like HIV-1 and HTLV-1 can be transmitted efficiently by direct contact between infected and target cells. For HIV-1, various modes of cell-to-cell transfer have been reported, including virological synapses, polysynapses, filopodial bridges, and nanotube-like structures. So far, only synapses and biofilms have been described for HTLV-1 transmission. Recently, Van Prooyen et al. [1] identified an additional mode of HTLV-1 transmission through cellular conduits induced by the viral accessory protein p8. Keywords: HTLV-1; HIV-1; cell-to-cell transfer; virological synapses; cellular conduits; p8; p12; Nef Human T-cell leukemia virus type 1 (HTLV-1) is the causative agent of adult T-cell leukemia/lymphoma (ATLL), a rare but aggressive T-cell lymphoproliferation. Infection by HTLV-1 is al