a new resorbable device for ligation of blood vessels - a pilot study一个新的血管结扎resorbable装置u2014u2014一个试点研究.pdfVIP

Höglund et al. Acta Veterinaria Scandinavica 2011, 53:47 /content/53/1/47 RESEARCH Open Access A new resorbable device for ligation of blood vessels - A pilot study 1* 1 2 3 4 1 Odd V Höglund , Ragnvi Hagman , Kerstin Olsson , Jonas Mindemark , Niklas Borg and Anne-Sofie Lagerstedt Abstract Background: During surgery, controlled haemostasis to prevent blood loss is vital for a successful outcome. It can be difficult to ligate vessels located deep in the abdomen. A device that is easy to use and enables secure ligatures could be beneficial. Cable ties made of nylon have been used for ligation but the non-resorbable material caused tissue reactions. The objective of this study was to use a resorbable material to construct a device with a self-locking mechanism and to test its mechanical strength and ligation efficiency. Methods: The device was manufactured by injection moulding of polydioxanone, a resorbable polymer used for suture materials. Polydioxanone with inherent viscosities of 1.9 dL/g and 1.3 dL/g were tested. The device consisted of a perforated flexible band which could be pulled through a case with a locking mechanism. After a first version of the device had been tested, some improvements were made. The locking case was downsized, corners were rounded off, the band was made thicker and the mould was redesigned to produce longer devices. Tensile tests were performed with the second version. The first version of the device was used to ligate the ovarian pedicle in a euthanized dog and to test echogenicity of the device with ultrasound. Compression of vessels of the ovarian pedicle was examined by histology. Both versions of the device were t