a prospective cohort study of biomarkers of prenatal tobacco smoke exposure the correlation between serum and meconium and their association with infant birth weight前瞻性群组研究产前烟草烟雾暴露生物标志物的血清和胎粪和他们之间的关系与婴儿出生体重.pdfVIP

Braun et al. Environmental Health 2010, 9:53 /content/9/1/53 RESEARCH Open Access A prospective cohort study of biomarkers of prenatal tobacco smoke exposure: the correlation between serum and meconium and their association with infant birth weight 1* 1 1 1 2 3 3 Joe M Braun , Julie L Daniels , Charles Poole , Andrew F Olshan , Richard Hornung , John T Bernert , Yang Xia , 4 5 2,6 Cynthia Bearer , Dana Boyd Barr , Bruce P Lanphear Abstract Background: The evaluation of infant meconium as a cumulative matrix of prenatal toxicant exposure requires comparison to established biomarkers of prenatal exposure. Methods: We calculated the frequency of detection and concentration of tobacco smoke metabolites measured in meconium (nicotine, cotinine, and trans-3′-hydroxycotinine concentrations) and three serial serum cotinine concentrations taken during the latter two-thirds of pregnancy among 337 mother-infant dyads. We estimated the duration and intensity of prenatal tobacco smoke exposure using serial serum cotinine concentrations and calculated geometric mean meconium tobacco smoke metabolite concentrations according to prenatal exposure. We also compared the estimated associations between these prenatal biomarkers and infant birth weight using linear regression. Results: We detected nicotine (80%), cotinine (69%), and trans-3′-hydroxycotinine (57%) in most meconium samples. Meconium tobacco smoke metabolite concentrations were positively associated with serum cotinine concentrations and increased with the number of serum cotinine measurements consistent with secondhand or active tobacco smoke exposure. Like serum cotinine, meconiu