activated partial thromboplastin time waveform analysis as specific sepsis marker in cardiopulmonary bypass surgery激活局部血栓形成质时间波形分析在心肺旁路手术具体败血症标记.pdfVIP

Schneider et al. Critical Care 2010, 14:104 /content/14/1/104 COMMENTARY Activated partial thromboplastin time waveform analysis as specii c sepsis marker in cardiopulmonary bypass surgery Christian P Schneider*, Martin K Angele and Wolfgang H Hartl See related research by Delannoy et al., /content/13/6/R180 possess a high degree of accuracy and for which the Abstract results can be obtained in a very short time. For patients Throughout the last years, several new diagnostic after cardiopulmonary bypass surgery, a recent publica- biomarkers have been introduced into clinical routine tion demonstrated that an activated partial thrombo- to identify a systemic inl ammatory response syndrome plastin time biphasic waveform (BPW) analysis was able (SIRS) or a septic state and to discriminate between to discriminate between sepsis and nonseptic systemic these two entities. According to studies in selected infl ammatory response syndrome (SIRS) with a sensi- patients, measurement of these biomarkers may be tivity of 100% and a specifi city of 93% [1]. In all patients, advantageous under certain clinical conditions. On an pneumonia was the septic focus. Compared with BPW individual basis, however, these sepsis markers usually analysis, the specifi city and sensitivity of C-reactive lack an adequate negative or positive predictive power. protein (CRP) and procalcitonin (PCT) were inferior Therefore, physicians in charge still have to rely on a with respect to pneumonia prediction. comb