血、尿、腹水ⅲ型前胶原肽联合检测在肝脏疾病中的诊断价值(Diagnostic value of combined detection of procollagen and peptide in blood, urine and ascites in liver diseases).docVIP
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血、尿、腹水ⅲ型前胶原肽联合检测在肝脏疾病中的诊断价值(Diagnostic value of combined detection of procollagen and peptide in blood, urine and ascites in liver diseases)
血、尿、腹水ⅲ型前胶原肽联合检测在肝脏疾病中的诊断价值(Diagnostic value of combined detection of procollagen and peptide in blood, urine and ascites in liver diseases)
Diagnostic value of combined detection of blood type, urine and ascitic fluid type procollagen procollagen in liver diseases
2011-05-10 Liu Dongping, Zhang Li, Fu Baoyu
[Abstract] Objective To observe the effect of chronic active hepatitis, liver cirrhosis, ascites, urine and blood serum procollagen peptide (P P) synchronous changes in content, the serum contents of P and P III transaminase (ALT), total bilirubin (TBIL), total serum albumin (A) were determined by correlation value. Evaluation of P P in diagnosis of liver diseases. Methods the content of P, III and P was determined by radioimmunoassay. The P III P content in ascites were significantly higher than those of P III P content in serum and urine, significant difference (P0.01), with 130 g/L for the critical value calculation of the 95% confidence interval of P III P sensitivity was 98.7%, 95.3%, urinary ascites blood 81.5%, specificity was 96.5%, 94.1% blood and urine ascites 92.3%, the serum P III P content and ALT, TBIL were positively correlated negatively with A, significant difference (P0.05). Conclusion chronic active hepatitis, liver cirrhosis, ascites in blood and urine P III P detection can obtain high sensitivity and specificity, blood P III P content not only has a certain value in the diagnosis of liver fibrosis, but also has a certain clinical significance in reflecting liver function and liver damage degree of cell necrosis.
[Keywords] type III procollagen peptide, chronic active hepatitis, liver cirrhosis
Type III procollagen (P III P) determination in recent years is used to determine a new diagnostic index of hepatic fibrosis in 1, changes of P III P serum content estimation, the progress of the severity and prognosis of liver fibrosis were observed and changes in regulation and control of P III P observation of liver fibrosis has curative effect. Mor
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