adherence to medication for the treatment of psychosis rates and risk factors in an ethiopian population坚持药物治疗精神病的利率和风险因素在埃塞俄比亚人口.pdfVIP

Alene et al. BMC Pharmacology and Toxicology 2012, 12:10 /12/1/10 RESEARCH ARTICLE Open Access Adherence to medication for the treatment of psychosis: rates and risk factors in an Ethiopian population 1 2 3 4 1 3* Menna Alene , Michael D Wiese , Mulugeta T Angamo , Beata V Bajorek , Elias A Yesuf and Nasir Tajure Wabe Abstract Background: Medication-taking behavior, specifically non-adherence, is significantly associated with treatment outcome and is a major cause of relapse in the treatment of psychotic disorders. Non-adherence can be multifactorial; however, the rates and associated risk factors in an Ethiopian population have not yet been elucidated. The principal aim of this study was to evaluate adherence rates to antipsychotic medications, and secondarily to identify potential factors associated with non-adherence, among psychotic patients at tertiary care teaching hospital in Southwest Ethiopia. Methods: A cross-sectional study was conducted over a 2-month period in 2009 (January 15th to March 20th) at the Jimma University Specialized Hospital. Adherence was computed using both a compliant fill rate method and self-reporting via a structured patient interview (focusing on how often regular medication doses were missed altogether, and whether they missed taking their doses on time). Data were analyzed using SPSS for windows version 16.0, and chi-square and Pearsons r tests were used to determine the statistical significance of the association of variables with adherence. Result: Three hundred thirty six patients were included in the study. A total of 75.6% were diagnosed with schizophrenia, while the others were diagnosed with other psychotic disorders. M