原创力文档adiponectin is a potential catabolic mediator in osteoarthritis cartilage脂联素是一个潜在的降解中介在骨关节炎软骨.pdfVIP
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adiponectin is a potential catabolic mediator in osteoarthritis cartilage脂联素是一个潜在的降解中介在骨关节炎软骨
Kang et al. Arthritis Research Therapy 2010, 12:R231
/content/12/6/R231
RESEARCH ARTICLE Open Access
Adiponectin is a potential catabolic mediator in
osteoarthritis cartilage
1 1,2* 3 3 4 5
Eun Ha Kang , Yun Jong Lee , Tae Kyun Kim , Chong Bum Chang , Jin-Haeng Chung , Kichul Shin ,
Eun Young Lee2,5, Eun Bong Lee2,5, Yeong Wook Song2,5
Abstract
Introduction: Adiponectin has been implicated in the pathogenesis of osteoarthritis (OA). We studied the effects
of adiponectin on the OA cartilage homeostasis.
Methods: Immunohistochemical analysis was performed to evaluate differential expression of adiponectin
receptors (AdipoRs) in nonlesional and lesional areas of OA cartilage. Cartilage and chondrocytes from the knee
joints of primary OA patients were cultured in the presence of adiponectin (0~30 μg/ml). The levels of total nitric
oxide (NO), matrix metalloproteinase (MMP)-1, -3, and -13, and tissue inhibitor of metalloproteinase (TIMP)-1 were
measured in the conditioned media. The levels of inducible NO synthase (iNOS) and MMPs were determined with
the quantitative real-time reverse transcription-polymerase chain reaction. The concentrations of collagenase-
cleaved type II collagen neoepitope (C1-2C) were determined in the supernatant of adiponectin-stimulated OA
cartilage explants. The effects of kinase and NOS inhibitors were evaluated in the adiponectin-stimulated
chondrocytes.
Results: The expression levels of both AdipoR1 and AdipoR2 were significantly higher in lesional than in
nonlesional areas of OA cartilage. The increased rate of AdipoR1-positive chondrocytes was twice that of AdipoR2-
positive chondrocytes when compared between nonlesional and lesional areas. Adiponectin-stimula
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