adolescent type 1 diabetes cardio-renal intervention trial (addit)青少年1型糖尿病cardio-renal干预试验(附加).pdfVIP

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adolescent type 1 diabetes cardio-renal intervention trial (addit)青少年1型糖尿病cardio-renal干预试验(附加).pdf

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adolescent type 1 diabetes cardio-renal intervention trial (addit)青少年1型糖尿病cardio-renal干预试验(附加)

BMC Pediatrics BioMed Central Study protocol Open Access Adolescent type 1 Diabetes cardio-renal Intervention Trial (AdDIT) The Adolescent type 1 Diabetes cardio-renal Intervention Trial Research Group Address: Department of Paediatrics, University of Cambridge, Level 8 Box 116, Addenbrookes Hospital, Hills Road, Cambridge, CB2 0QQ, UK Email: The Adolescent type 1 Diabetes cardio-renal Intervention Trial Research Group - dbd25@cam.ac.uk Published: 17 December 2009 Received: 23 October 2009 Accepted: 17 December 2009 BMC Pediatrics 2009, 9:79 doi:10.1186/1471-2431-9-79 This article is available from: /1471-2431/9/79 © 2009 The Adolescent type 1 Diabetes cardio-renal Intervention Trial Research Group and Dunger; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: The prognosis for young people diagnosed with diabetes during childhood remains poor and this is mainly related to the long-term risk of developing vascular complications. Microalbuminuria identifies subjects at risk for diabetic nephropathy (DN) and cardiovascular disease (CVD). It is often detected in adolescence but is rarely treated before the age of 18 years, as at the end of puberty albumin excretion may decline and in some subjects will return into the