action of natural products on p2 receptors a reinvented era for drug discovery天然产物在p2受体作用改造药物发现的时代.pdfVIP

Molecules 2012, 17, 13009-13025; doi:10.3390/molecules171113009 OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Review Action of Natural Products on P2 Receptors: A Reinvented Era for Drug Discovery Robson Faria 1, Leonardo Ferreira 1, Rômulo Bezerra 1, Valber Frutuoso 2 and Luiz Alves 1,* 1 Laboratory of Cellular Communication, Oswaldo Cruz Foundation, 4365 Rio de Janeiro, Brazil; E-Mails: robson.xavier@ (R.F.); leonardobraga12@ (L.F.); romulo@ioc.fiocruz.br (R.B.) 2 Laboratory of Immnopharmacology, Oswaldo Cruz Foundation, 4365 Rio de Janeiro, Brazil; E-Mail: frutuoso@ioc.fiocruz.br * Author to whom correspondence should be addressed; E-Mail: alveslaa@; Tel.: +55-21-2562-1809; Fax: +55-21-2562-1772. Received: 7 September 2012; in revised form: 12 October 2012 / Accepted: 24 October 2012 / Published: 1 November 2012 Abstract: Natural products contribute significantly to available drug therapies and have been a rich source for scientific investigation. In general, due to their low cost and traditional use in some cultures, they are an object of growing interest as alternatives to synthetic drugs. With several diseases such as cancer, and inflammatory and neuropathic diseases having been linked to the participation of purinergic (P2) receptors, there has been a flurry of investigations on ligands within natural products. Thirty-four different sources of these compounds have been found so far, that have shown either agonistic or antagonistic effects on P2 r