原创力文档alcohol and cardiovascular disease—modulation of vascular cell function酒精和心血管disease-modulation血管细胞的功能.pdfVIP
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alcohol and cardiovascular disease—modulation of vascular cell function酒精和心血管disease-modulation血管细胞的功能
Nutrients 2012, 4, 297-318; doi:10.3390/nu4040297
OPEN ACCESS
nutrients
ISSN 2072-6643
/journal/nutrients
Review
Alcohol and Cardiovascular Disease—Modulation of Vascular
Cell Function
Paul A. Cahill 1 and Eileen M. Redmond 2,*
1 School of Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland;
E-Mail: paul.cahill@dcu.ie
2 Department of Surgery, University of Rochester Medical Center, 601 Elmwood Ave.,
Rochester, NY 14642, USA
* Author to whom correspondence should be addressed;
E-Mail: Eileen_Redmond@; Tel.: +1-585-275-2870.
Received: 7 March 2012; in revised form: 12 April 2012 / Accepted: 16 April 2012 /
Published: 19 April 2012
Abstract: Alcohol is a commonly used drug worldwide. Epidemiological studies have
identified alcohol consumption as a factor that may either positively or negatively
influence many diseases including cardiovascular disease, certain cancers and dementia.
Often there seems to be a differential effect of various drinking patterns, with frequent
moderate consumption of alcohol being salutary and binge drinking or chronic abuse
being deleterious to one’s health. A better understanding of the cellular and molecular
mechanisms mediating the many effects of alcohol consumption is beginning to emerge, as
well as a clearer picture as to whether these effects are due to the direct actions of alcohol
itself, or caused in part by its metabolites, e.g
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